R86H (p.Arg86His) variant of NRXN2 (Neurexin-2)
R86H (p.Arg86His) in NRXN2 (Neurexin-2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
R86H (p.Arg86His) variant details
- p.Arg86His
- TOPMed rs1459898358
- gnomAD rs1459898358
- Missense
- Variant Prioritization Score for Impact Estimate 0.458
- REVEL 0.33
- MetaLR 0.33
- MetaSVM -0.44
- CADD 22.70
- PolyPhen-2 0.20
- SIFT 0.11
- Most common in the Ashkenazi Jewish population (allele frequency 4.2e-05)
- Structural context available