R58S (p.Arg58Ser) variant of NRXN2 (Neurexin-2)
R58S (p.Arg58Ser) in NRXN2 (Neurexin-2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.63 / 1. The record also includes population frequency data and structural context.
R58S (p.Arg58Ser) variant details
- p.Arg58Ser
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.633
- REVEL 0.67
- MetaLR 0.56
- MetaSVM 0.13
- CADD 26.20
- PolyPhen-2 0.88
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available