P157S (p.Pro157Ser) variant of NRXN2 (Neurexin-2)
P157S (p.Pro157Ser) in NRXN2 (Neurexin-2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
P157S (p.Pro157Ser) variant details
- p.Pro157Ser
- TOPMed rs1248456352
- gnomAD rs1248456352
- Missense
- Variant Prioritization Score for Impact Estimate 0.389
- REVEL 0.21
- MetaLR 0.24
- MetaSVM -0.87
- CADD 22.00
- PolyPhen-2 0.10
- SIFT 0.07
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available