P157L (p.Pro157Leu) variant of NRXN2 (Neurexin-2)
P157L (p.Pro157Leu) in NRXN2 (Neurexin-2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data and structural context.
P157L (p.Pro157Leu) variant details
- p.Pro157Leu
- TOPMed rs2057120755
- gnomAD rs2057120755
- Missense
- Variant Prioritization Score for Impact Estimate 0.547
- REVEL 0.50
- MetaLR 0.43
- MetaSVM -0.23
- CADD 23.20
- PolyPhen-2 0.03
- SIFT 0.04
- Most common in the Latino/Admixed American population (allele frequency 6.6e-05)
- Structural context available