P11L (p.Pro11Leu) variant of NRXN2 (Neurexin-2)
P11L (p.Pro11Leu) in NRXN2 (Neurexin-2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
P11L (p.Pro11Leu) variant details
- p.Pro11Leu
- TOPMed rs2057171687
- gnomAD rs2057171687
- Missense
- Variant Prioritization Score for Impact Estimate 0.18
- REVEL 0.11
- MetaLR 0.09
- MetaSVM -1.03
- CADD 16.30
- PolyPhen-2 0.00
- SIFT 0.15
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available