L161F (p.Leu161Phe) variant of NRXN2 (Neurexin-2)
L161F (p.Leu161Phe) in NRXN2 (Neurexin-2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
L161F (p.Leu161Phe) variant details
- p.Leu161Phe
- gnomAD rs2057119472
- Missense
- Variant Prioritization Score for Impact Estimate 0.507
- REVEL 0.45
- MetaLR 0.52
- MetaSVM -0.17
- CADD 24.20
- PolyPhen-2 0.77
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available