L15P (p.Leu15Pro) variant of NRXN2 (Neurexin-2)
L15P (p.Leu15Pro) in NRXN2 (Neurexin-2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
L15P (p.Leu15Pro) variant details
- p.Leu15Pro
- TOPMed rs1464900506
- gnomAD rs1464900506
- Missense
- Variant Prioritization Score for Impact Estimate 0.223
- REVEL 0.09
- MetaLR 0.14
- MetaSVM -0.99
- CADD 15.30
- PolyPhen-2 0.02
- SIFT 0.32
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available