G154V (p.Gly154Val) variant of NRXN2 (Neurexin-2)
G154V (p.Gly154Val) in NRXN2 (Neurexin-2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.85 / 1. The record also includes population frequency data and structural context.
G154V (p.Gly154Val) variant details
- p.Gly154Val
- NCI-TCGA TCGA novel
- ExAC rs199786530
- gnomAD rs199786530
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.851
- REVEL 0.92
- MetaLR 0.85
- MetaSVM 0.90
- CADD 26.10
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available