D74N (p.Asp74Asn) variant of NRXN2 (Neurexin-2)
D74N (p.Asp74Asn) in NRXN2 (Neurexin-2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
D74N (p.Asp74Asn) variant details
- p.Asp74Asn
- ExAC rs775042347
- TOPMed rs775042347
- gnomAD rs775042347
- Missense
- Variant Prioritization Score for Impact Estimate 0.295
- REVEL 0.11
- MetaLR 0.13
- MetaSVM -0.95
- CADD 19.60
- PolyPhen-2 0.02
- SIFT 1.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available