Q74R (p.Gln74Arg) variant of NR3C1 (Glucocorticoid receptor)
Q74R (p.Gln74Arg) in NR3C1 (Glucocorticoid receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data, experimental measurements, and structural context.
Q74R (p.Gln74Arg) variant details
- p.Gln74Arg
- ExAC rs764541357
- TOPMed rs764541357
- gnomAD rs764541357
- Missense
- Variant Prioritization Score for Impact Estimate 0.149
- REVEL 0.05
- CADD 21.90
- PolyPhen-2 0.19
- SIFT 0.05
- Most common in the East Asian population (allele frequency 0.00025)
- Structural context available
- NR3C1 Zinc finger, nuclear hormone receptor-type domain domainome 1.0: score 0.043