Q74L (p.Gln74Leu) variant of NR3C1 (Glucocorticoid receptor)
Q74L (p.Gln74Leu) in NR3C1 (Glucocorticoid receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data, experimental measurements, and structural context.
Q74L (p.Gln74Leu) variant details
- p.Gln74Leu
- ExAC rs764541357
- TOPMed rs764541357
- gnomAD rs764541357
- Missense
- Variant Prioritization Score for Impact Estimate 0.146
- REVEL 0.04
- CADD 22.40
- PolyPhen-2 0.08
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- NR3C1 Zinc finger, nuclear hormone receptor-type domain domainome 1.0: score 0.043