M27T (p.Met27Thr) variant of NR3C1 (Glucocorticoid receptor)
M27T (p.Met27Thr) in NR3C1 (Glucocorticoid receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data, experimental measurements, and structural context.
M27T (p.Met27Thr) variant details
- p.Met27Thr
- ExAC rs778329686
- TOPMed rs778329686
- gnomAD rs778329686
- Missense
- Variant Prioritization Score for Impact Estimate 0.28
- REVEL 0.12
- CADD 23.50
- PolyPhen-2 0.05
- SIFT 0.01
- Most common in the South Asian population (allele frequency 2.3e-05)
- Structural context available
- NR3C1 Zinc finger, nuclear hormone receptor-type domain domainome 1.0: score -0.0003