K31R (p.Lys31Arg) variant of NR3C1 (Glucocorticoid receptor)
K31R (p.Lys31Arg) in NR3C1 (Glucocorticoid receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, experimental measurements, and structural context.
K31R (p.Lys31Arg) variant details
- p.Lys31Arg
- TOPMed rs943559773
- gnomAD rs943559773
- Missense
- Variant Prioritization Score for Impact Estimate 0.299
- REVEL 0.07
- CADD 22.70
- PolyPhen-2 0.40
- SIFT 0.17
- Most common in the African/African-American population (allele frequency 7.2e-05)
- Structural context available
- NR3C1 Zinc finger, nuclear hormone receptor-type domain domainome 1.0: score -0.0336