G35E (p.Gly35Glu) variant of NR3C1 (Glucocorticoid receptor)
G35E (p.Gly35Glu) in NR3C1 (Glucocorticoid receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G35E (p.Gly35Glu) variant details
- p.Gly35Glu
- ESP rs374312820
- ExAC rs374312820
- TOPMed rs374312820
- gnomAD rs374312820
- Missense
- Variant Prioritization Score for Impact Estimate 0.482
- REVEL 0.27
- CADD 24.30
- PolyPhen-2 1.00
- SIFT 0.07
- Most common in the Non-Finnish European population (allele frequency 8.8e-05)
- Structural context available
- NR3C1 Zinc finger, nuclear hormone receptor-type domain domainome 1.0: score -0.0796