P22L (p.Pro22Leu) variant of NPR1 (P16066)
P22L (p.Pro22Leu) in NPR1 (P16066) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
P22L (p.Pro22Leu) variant details
- p.Pro22Leu
- TOPMed rs1281961171
- gnomAD rs1281961171
- Missense
- Variant Prioritization Score for Impact Estimate 0.155
- REVEL 0.18
- CADD 6.41
- PolyPhen-2 0.00
- SIFT 0.72
- Most common in the HGDP:YAKUT population (allele frequency 0.04)
- Structural context available