L23P (p.Leu23Pro) variant of NPR1 (P16066)
L23P (p.Leu23Pro) in NPR1 (P16066) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
L23P (p.Leu23Pro) variant details
- p.Leu23Pro
- rs994822671
- NCI-TCGA Cosmic COSV6414
- TOPMed rs994822671
- gnomAD rs994822671
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.201
- REVEL 0.23
- CADD 13.50
- PolyPhen-2 0.00
- SIFT 0.20
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the 1KG:MSL population (allele frequency 0.013)
- Structural context available