P66R (p.Pro66Arg) variant of NPPB (Natriuretic peptides B)
P66R (p.Pro66Arg) in NPPB (Natriuretic peptides B) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
P66R (p.Pro66Arg) variant details
- p.Pro66Arg
- TOPMed rs1280392538
- gnomAD rs1280392538
- Missense
- Variant Prioritization Score for Impact Estimate 0.246
- REVEL 0.07
- CADD 21.30
- PolyPhen-2 0.85
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available