L63H (p.Leu63His) variant of NPPA (Natriuretic peptides A)
L63H (p.Leu63His) in NPPA (Natriuretic peptides A) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data, published literature, and structural context.
L63H (p.Leu63His) variant details
- p.Leu63His
- gnomAD 1-11847375-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.252
- REVEL 0.14
- CADD 20.20
- PolyPhen-2 0.53
- SIFT 0.03
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available
- Literature evidence available