S4L (p.Ser4Leu) variant of NPM1 (Nucleophosmin)
S4L (p.Ser4Leu) in NPM1 (Nucleophosmin) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes structural context.
S4L (p.Ser4Leu) variant details
- p.Ser4Leu
- rs1363897984
- NCI-TCGA Cosmic COSV9974
- cosmic curated COSV99742
- gnomAD rs1363897984
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.323
- AlphaMissense 0.28
- MetaLR 0.10
- MetaSVM -0.98
- PolyPhen-2 0.02
- SIFT 0.02
- MutPred 0.22
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available