R45K (p.Arg45Lys) variant of NPM1 (Nucleophosmin)
R45K (p.Arg45Lys) in NPM1 (Nucleophosmin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
R45K (p.Arg45Lys) variant details
- p.Arg45Lys
- cosmic curated COSV10964
- TOPMed rs1770495635
- gnomAD rs1770495635
- Missense
- Variant Prioritization Score for Impact Estimate 0.417
- REVEL 0.16
- CADD 26.10
- PolyPhen-2 0.55
- SIFT 0.14
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available