L18F (p.Leu18Phe) variant of NPM1 (Nucleophosmin)
L18F (p.Leu18Phe) in NPM1 (Nucleophosmin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
L18F (p.Leu18Phe) variant details
- p.Leu18Phe
- gnomAD rs1446401368
- Missense
- Variant Prioritization Score for Impact Estimate 0.442
- REVEL 0.21
- CADD 27.60
- PolyPhen-2 0.64
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 9.6e-07)
- Structural context available