E127Q (p.Glu127Gln) variant of NPC1 (O15118)

E127Q (p.Glu127Gln) in NPC1 (O15118) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Niemann-Pick disease, type C1. The record also includes published literature and structural context.

E127Q (p.Glu127Gln) variant details