G35W (p.Gly35Trp) variant of NOTCH3 (Q9UM47)
G35W (p.Gly35Trp) in NOTCH3 (Q9UM47) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes population frequency data and structural context.
G35W (p.Gly35Trp) variant details
- p.Gly35Trp
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.535
- REVEL 0.55
- CADD 27.20
- PolyPhen-2 0.96
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available