G22S (p.Gly22Ser) variant of NOS3 (Nitric oxide synthase 3)
G22S (p.Gly22Ser) in NOS3 (Nitric oxide synthase 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
G22S (p.Gly22Ser) variant details
- p.Gly22Ser
- TOPMed rs1563206770
- Missense
- Variant Prioritization Score for Impact Estimate 0.304
- REVEL 0.18
- CADD 22.40
- PolyPhen-2 0.99
- SIFT 0.33
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available