R59W (p.Arg59Trp) variant of NOS1AP (O75052)
R59W (p.Arg59Trp) in NOS1AP (O75052) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
R59W (p.Arg59Trp) variant details
- p.Arg59Trp
- cosmic curated COSV10745
- ExAC rs780388688
- TOPMed rs780388688
- gnomAD rs780388688
- Missense
- Variant Prioritization Score for Impact Estimate 0.407
- REVEL 0.32
- CADD 29.50
- PolyPhen-2 0.56
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available