D140G (p.Asp140Gly) variant of NOD1 (Q9Y239)
D140G (p.Asp140Gly) in NOD1 (Q9Y239) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.65 / 1. The record also includes population frequency data and structural context.
D140G (p.Asp140Gly) variant details
- p.Asp140Gly
- NCI-TCGA Cosmic COSV9976
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.652
- REVEL 0.66
- CADD 26.30
- PolyPhen-2 1.00
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 0.00031)
- Structural context available