F75L (p.Phe75Leu) variant of NLRP3 (Q96P20)
F75L (p.Phe75Leu) in NLRP3 (Q96P20) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data, published literature, and structural context.
F75L (p.Phe75Leu) variant details
- p.Phe75Leu
- rs1244421162
- gnomAD 1-247419017-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.443
- REVEL 0.35
- CADD 22.90
- PolyPhen-2 0.15
- SIFT 0.05
- Population evidence available
- Structural context available
- Literature evidence available