F25L (p.Phe25Leu) variant of NLRP3 (Q96P20)
F25L (p.Phe25Leu) in NLRP3 (Q96P20) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data, published literature, and structural context.
F25L (p.Phe25Leu) variant details
- p.Phe25Leu
- rs149709470
- gnomAD 1-247418869-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.546
- REVEL 0.67
- CADD 22.90
- PolyPhen-2 0.88
- SIFT 0.00
- Population evidence available
- Structural context available
- Literature evidence available