S118Y (p.Ser118Tyr) variant of NLGN4X (Neuroligin-4, X-linked)
S118Y (p.Ser118Tyr) in NLGN4X (Neuroligin-4, X-linked) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
S118Y (p.Ser118Tyr) variant details
- p.Ser118Tyr
- gnomAD rs977524047
- Missense
- Variant Prioritization Score for Impact Estimate 0.267
- REVEL 0.17
- MetaLR 0.13
- MetaSVM -0.96
- CADD 10.60
- PolyPhen-2 0.03
- SIFT 1.00
- Most common in the African/African-American population (allele frequency 3.8e-05)
- Structural context available