P81T (p.Pro81Thr) variant of NLGN4X (Neuroligin-4, X-linked)
P81T (p.Pro81Thr) in NLGN4X (Neuroligin-4, X-linked) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data and structural context.
P81T (p.Pro81Thr) variant details
- p.Pro81Thr
- TOPMed rs1245032090
- gnomAD rs1245032090
- Missense
- Variant Prioritization Score for Impact Estimate 0.641
- REVEL 0.66
- MetaLR 0.61
- MetaSVM 0.48
- CADD 22.70
- PolyPhen-2 0.94
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 3.3e-05)
- Structural context available