P4S (p.Pro4Ser) variant of NLGN4X (Neuroligin-4, X-linked)
P4S (p.Pro4Ser) in NLGN4X (Neuroligin-4, X-linked) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
P4S (p.Pro4Ser) variant details
- p.Pro4Ser
- rs1277406866
- ClinGen CA412015664
- ClinVar RCV003440907
- TOPMed rs1277406866
- Likely benign
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.347
- REVEL 0.15
- MetaLR 0.11
- MetaSVM -0.82
- CADD 10.20
- PolyPhen-2 0.00
- SIFT 0.90
- ClinVar: Likely benign (not provided)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the Non-Finnish European population (allele frequency 1.9e-05)
- Structural context available