P11S (p.Pro11Ser) variant of NLGN4X (Neuroligin-4, X-linked)
P11S (p.Pro11Ser) in NLGN4X (Neuroligin-4, X-linked) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
P11S (p.Pro11Ser) variant details
- p.Pro11Ser
- cosmic curated COSV52002
- ExAC rs769097463
- TOPMed rs769097463
- gnomAD rs769097463
- Missense
- Variant Prioritization Score for Impact Estimate 0.183
- REVEL 0.16
- MetaLR 0.11
- MetaSVM -1.06
- CADD 7.30
- PolyPhen-2 0.00
- SIFT 0.34
- Most common in the African/African-American population (allele frequency 3.3e-05)
- Structural context available