P111L (p.Pro111Leu) variant of NLGN4X (Neuroligin-4, X-linked)
P111L (p.Pro111Leu) in NLGN4X (Neuroligin-4, X-linked) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data and structural context.
P111L (p.Pro111Leu) variant details
- p.Pro111Leu
- NCI-TCGA Cosmic COSV5201
- cosmic curated COSV52016
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.555
- REVEL 0.57
- MetaLR 0.41
- MetaSVM -0.34
- CADD 23.50
- PolyPhen-2 1.00
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available