H121R (p.His121Arg) variant of NLGN4X (Neuroligin-4, X-linked)
H121R (p.His121Arg) in NLGN4X (Neuroligin-4, X-linked) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
H121R (p.His121Arg) variant details
- p.His121Arg
- TOPMed rs1405905840
- gnomAD rs1405905840
- Missense
- Variant Prioritization Score for Impact Estimate 0.229
- REVEL 0.16
- MetaLR 0.07
- MetaSVM -1.05
- CADD 13.80
- PolyPhen-2 0.01
- SIFT 0.13
- Most common in the African/African-American population (allele frequency 6.5e-05)
- Structural context available