S21T (p.Ser21Thr) variant of NLGN3 (Neuroligin-3)
S21T (p.Ser21Thr) in NLGN3 (Neuroligin-3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data, published literature, and structural context.
S21T (p.Ser21Thr) variant details
- p.Ser21Thr
- gnomAD X-71147811-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.287
- REVEL 0.13
- CADD 14.10
- PolyPhen-2 0.08
- SIFT 0.81
- Most common in the African/African-American population (allele frequency 3.8e-05)
- Structural context available
- Literature evidence available