L5R (p.Leu5Arg) variant of NLGN3 (Neuroligin-3)
L5R (p.Leu5Arg) in NLGN3 (Neuroligin-3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
L5R (p.Leu5Arg) variant details
- p.Leu5Arg
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.362
- REVEL 0.31
- CADD 23.00
- PolyPhen-2 0.07
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3.8e-05)
- Structural context available