W66C (p.Trp66Cys) variant of NFKBIA (NF-kappa-B inhibitor alpha)
W66C (p.Trp66Cys) in NFKBIA (NF-kappa-B inhibitor alpha) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data and structural context.
W66C (p.Trp66Cys) variant details
- p.Trp66Cys
- NCI-TCGA Cosmic COSV5375
- NCI-TCGA Cosmic COSV9939
- cosmic curated COSV99395
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.515
- REVEL 0.37
- MetaLR 0.29
- MetaSVM -0.31
- CADD 32.00
- PolyPhen-2 0.53
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available