W11R (p.Trp11Arg) variant of NFKBIA (NF-kappa-B inhibitor alpha)
W11R (p.Trp11Arg) in NFKBIA (NF-kappa-B inhibitor alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
W11R (p.Trp11Arg) variant details
- p.Trp11Arg
- TOPMed rs1306827115
- gnomAD rs1306827115
- Missense
- Variant Prioritization Score for Impact Estimate 0.444
- REVEL 0.52
- MetaLR 0.21
- MetaSVM -0.75
- CADD 18.50
- PolyPhen-2 0.00
- SIFT 0.35
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available