P8S (p.Pro8Ser) variant of NFKBIA (NF-kappa-B inhibitor alpha)
P8S (p.Pro8Ser) in NFKBIA (NF-kappa-B inhibitor alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
P8S (p.Pro8Ser) variant details
- p.Pro8Ser
- gnomAD rs1356888768
- Missense
- Variant Prioritization Score for Impact Estimate 0.187
- REVEL 0.11
- MetaLR 0.26
- MetaSVM -0.91
- CADD 7.65
- PolyPhen-2 0.00
- SIFT 0.31
- Most common in the HGDP:JAPANESE population (allele frequency 0.018)
- Structural context available