L26M (p.Leu26Met) variant of NFKBIA (NF-kappa-B inhibitor alpha)
L26M (p.Leu26Met) in NFKBIA (NF-kappa-B inhibitor alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
L26M (p.Leu26Met) variant details
- p.Leu26Met
- ExAC rs200033269
- TOPMed rs200033269
- gnomAD rs200033269
- Missense
- Variant Prioritization Score for Impact Estimate 0.279
- REVEL 0.17
- MetaLR 0.34
- MetaSVM -0.66
- CADD 22.40
- PolyPhen-2 0.21
- SIFT 0.16
- Most common in the Finnish in Finland (FIN) population (allele frequency 9.8e-05)
- Structural context available