K87N (p.Lys87Asn) variant of NFKBIA (NF-kappa-B inhibitor alpha)
K87N (p.Lys87Asn) in NFKBIA (NF-kappa-B inhibitor alpha) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
K87N (p.Lys87Asn) variant details
- p.Lys87Asn
- NCI-TCGA Cosmic COSV5375
- cosmic curated COSV53754
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.353
- REVEL 0.23
- MetaLR 0.53
- MetaSVM 0.01
- CADD 23.20
- PolyPhen-2 0.87
- SIFT 0.06
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available