F77L (p.Phe77Leu) variant of NFKBIA (NF-kappa-B inhibitor alpha)
F77L (p.Phe77Leu) in NFKBIA (NF-kappa-B inhibitor alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
F77L (p.Phe77Leu) variant details
- p.Phe77Leu
- gnomAD rs1436082564
- Missense
- Variant Prioritization Score for Impact Estimate 0.327
- REVEL 0.14
- MetaLR 0.21
- MetaSVM -0.79
- CADD 23.70
- PolyPhen-2 0.01
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available