V24L (p.Val24Leu) variant of NEDD4L (E3 ubiquitin-protein ligase NEDD4-like)
V24L (p.Val24Leu) in NEDD4L (E3 ubiquitin-protein ligase NEDD4-like) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes experimental measurements and structural context.
V24L (p.Val24Leu) variant details
- p.Val24Leu
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.504
- REVEL 0.47
- ESM-1b 0.52
- AlphaMissense 0.82
- MetaLR 0.60
- MetaSVM -0.01
- SIFT 0.30
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available
- NEDD4L WW domain domainome 1.0: score -0.76