V24I (p.Val24Ile) variant of NEDD4L (E3 ubiquitin-protein ligase NEDD4-like)
V24I (p.Val24Ile) in NEDD4L (E3 ubiquitin-protein ligase NEDD4-like) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data, experimental measurements, and structural context.
V24I (p.Val24Ile) variant details
- p.Val24Ile
- gnomAD rs1209086085
- Missense
- Variant Prioritization Score for Impact Estimate 0.492
- REVEL 0.37
- ESM-1b 0.24
- AlphaMissense 0.23
- MetaLR 0.46
- MetaSVM -0.37
- CADD 23.30
- Most common in the 1KG:FIN population (allele frequency 0.0051)
- Structural context available
- NEDD4L WW domain domainome 1.0: score -0.76