L58F (p.Leu58Phe) variant of NEDD4L (E3 ubiquitin-protein ligase NEDD4-like)
L58F (p.Leu58Phe) in NEDD4L (E3 ubiquitin-protein ligase NEDD4-like) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes structural context.
L58F (p.Leu58Phe) variant details
- p.Leu58Phe
- rs2148411903
- ClinGen CA402715670
- ClinVar RCV002209818
- Ensembl rs2148411903
- Likely benign
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.396
- ESM-1b 0.56
- AlphaMissense 0.66
- MetaLR 0.15
- MetaSVM -0.88
- PolyPhen-2 1.00
- SIFT 0.08
- ClinVar: Likely benign (not provided)
- EBI: Likely benign
- UniProt: Likely benign
- Structural context available