L22V (p.Leu22Val) variant of NEDD4L (E3 ubiquitin-protein ligase NEDD4-like)
L22V (p.Leu22Val) in NEDD4L (E3 ubiquitin-protein ligase NEDD4-like) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes experimental measurements and structural context.
L22V (p.Leu22Val) variant details
- p.Leu22Val
- TOPMed rs901451076
- gnomAD rs901451076
- Missense
- Variant Prioritization Score for Impact Estimate 0.512
- REVEL 0.43
- ESM-1b 1.00
- AlphaMissense 0.27
- MetaLR 0.62
- MetaSVM 0.07
- SIFT 0.64
- Structural context available
- NEDD4L WW domain domainome 1.0: score -0.455