K67T (p.Lys67Thr) variant of NEDD4L (E3 ubiquitin-protein ligase NEDD4-like)
K67T (p.Lys67Thr) in NEDD4L (E3 ubiquitin-protein ligase NEDD4-like) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
K67T (p.Lys67Thr) variant details
- p.Lys67Thr
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.528
- ESM-1b 1.00
- AlphaMissense 0.98
- CADD 20.20
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the HGDP:SARDINIAN population (allele frequency 0.056)
- Structural context available