I66V (p.Ile66Val) variant of NEDD4L (E3 ubiquitin-protein ligase NEDD4-like)
I66V (p.Ile66Val) in NEDD4L (E3 ubiquitin-protein ligase NEDD4-like) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
I66V (p.Ile66Val) variant details
- p.Ile66Val
- Ensembl rs646509
- Missense
- Variant Prioritization Score for Impact Estimate 0.401
- REVEL 0.22
- ESM-1b 1.00
- AlphaMissense 0.18
- MetaLR 0.19
- MetaSVM -0.87
- CADD 19.10
- Most common in the Finnish in Finland (FIN) population (allele frequency 5.6e-05)
- Structural context available