I66N (p.Ile66Asn) variant of NEDD4L (E3 ubiquitin-protein ligase NEDD4-like)
I66N (p.Ile66Asn) in NEDD4L (E3 ubiquitin-protein ligase NEDD4-like) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.65 / 1. The record also includes population frequency data and structural context.
I66N (p.Ile66Asn) variant details
- p.Ile66Asn
- ExAC rs774104851
- gnomAD rs774104851
- Missense
- Variant Prioritization Score for Impact Estimate 0.648
- REVEL 0.63
- ESM-1b 1.00
- AlphaMissense 0.98
- MetaLR 0.52
- MetaSVM 0.03
- CADD 27.50
- Most common in the HGDP:TUSCAN population (allele frequency 1)
- Structural context available