H87L (p.His87Leu) variant of NEDD4L (E3 ubiquitin-protein ligase NEDD4-like)
H87L (p.His87Leu) in NEDD4L (E3 ubiquitin-protein ligase NEDD4-like) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
H87L (p.His87Leu) variant details
- p.His87Leu
- ExAC rs760779722
- gnomAD rs760779722
- Missense
- Variant Prioritization Score for Impact Estimate 0.607
- REVEL 0.61
- ESM-1b 1.00
- AlphaMissense 0.90
- MetaLR 0.32
- MetaSVM -0.35
- CADD 24.30
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available